期刊
SCHIZOPHRENIA BULLETIN
卷 41, 期 1, 页码 44-56出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbu132
关键词
schizophrenia; long-term potentiation; glutamate; dopamine; GABA; MRS; PET; SPECT
类别
资金
- Ontario Graduate Scholarship
- Ontario Mental Health Foundation (OMHF) Scholarship
- Brain Canada
- Brain and Behavior Research Foundation
- Canadian Foundation for Innovation
- Canadian Institutes of Health Research (CIHR)
- Ontario Ministry of Health and Long-Term Care
- Ontario Ministry of Research and Innovation
- US National Institute of Health (NIH)
- W. Garfield Weston Foundation
- NIH
- CIHR
- OMHF
- CONACyT
- ICyTDF
- Brain & Behavior Research Foundation (NARSAD)
- Janssen
- BrainswayInc
- SepracorInc
- AstraZeneca
Cognitive deficits are commonly observed in patients with schizophrenia. Converging lines of evidence suggest that these deficits are associated with impaired long-term potentiation (LTP). In our systematic review, this hypothesis is evaluated using neuroimaging literature focused on proton magnetic resonance spectroscopy, positron emission tomography, and single-photon emission computed tomography. The review provides evidence for abnormal dopaminergic, GABAergic, and glutamatergic neurotransmission in antipsychotic-naive/free patients with schizophrenia compared with healthy controls. The review concludes with a model illustrating how these abnormalities could lead to impaired LTP in patients with schizophrenia and consequently cognitive deficits.
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