期刊
SCHIZOPHRENIA BULLETIN
卷 39, 期 3, 页码 485-489出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbt006
关键词
Toxoplasma; CD8 T cells; exhaustion; PD-1; schizophrenia
类别
资金
- National Institutes of Health [AI-33325]
Although the highest numbers of studies linking an infectious agent with schizophrenia has involved the parasite Toxoplasma gondii, the mechanistic underpinnings of this correlation has remained unaddressed. Incidentally, CD8 T cells, which play a pivotal role in mediating long-term immunity to Toxoplasma, are downregulated in schizophrenia patients. Recent studies have demonstrated that CD8 response is also impaired during chronic toxoplasmosis in murine models. In light of these new findings, in this article, we discuss the potential role of CD8 T cells in causing altered mental status in Toxoplasma seropositive schizophrenia patients.
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