期刊
SCHIZOPHRENIA BULLETIN
卷 37, 期 3, 页码 493-503出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbr029
关键词
GABA; working memory; parvalbumin; pyramidal; cholecystokinin; cannabinoid
类别
资金
- National Institute of Health [MH051234, DA023109, MH084053]
Schizophrenia is a disorder of cognitive neurodevelopment with characteristic abnormalities in working memory attributed, at least in part, to alterations in the circuitry of the dorsolateral prefrontal cortex. Various environmental exposures from conception through adolescence increase risk for the illness, possibly by altering the developmental trajectories of prefrontal cortical circuits. Macaque monkeys provide an excellent model system for studying the maturation of prefrontal cortical circuits. Here, we review the development of glutamatergic and gamma-aminobutyric acid (GABA)-ergic circuits in macaque monkey prefrontal cortex and discuss how these trajectories may help to identify sensitive periods during which environmental exposures, such as those associated with increased risk for schizophrenia, might lead to the types of abnormalities in prefrontal cortical function present in schizophrenia.
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