期刊
SCHIZOPHRENIA BULLETIN
卷 35, 期 5, 页码 959-972出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbn022
关键词
animal model; cytokines; fetus; infection; neurodevelopment; pregnancy; schizophrenia
类别
资金
- Swiss Federal Institute of Technology (ETH) Zurich
- Swiss National Science Foundation
- National Centre of Competence in research
Maternal infection during pregnancy increases the risk of schizophrenia and other brain disorders of neurodevelopmental origin in the offspring. A multitude of infectious agents seem to be involved in this association. Therefore, it has been proposed that factors common to the immune response to a wide variety of bacterial and viral pathogens may be the critical link between prenatal infection and postnatal brain and behavioral pathology. More specifically, it has been suggested that the maternal induction of pro-inflammatory cytokines may mediate the neurodevelopmental effects of maternal infections. Here, we review recent findings from in vitro and in vivo investigations supporting this hypothesis and further emphasize the influence of enhanced anti-inflammatory cytokine signaling on early brain development. Disruption of the fetal brain balance between pro- and anti-inflammatory cytokine signaling may thus represent a key mechanism involved in the precipitation of schizophrenia-related pathology following prenatal maternal infection and innate immune imbalances.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据