期刊
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
卷 22, 期 1, 页码 104-112出版社
WILEY
DOI: 10.1111/j.1600-0838.2010.01132.x
关键词
fibromyalgia syndrome; physical activity; inflammation; IL-1 ss; IL-6; IL-10; TNFa; CRP
资金
- Consejeria de Economia, Comercio e Innovacion, Junta de Extremadura
- Fondo Social Europeo [PRI06A172, PRI09A003]
- Ministerio de Ciencia e Innovacion-FEDER, Spain [DEP 2009-10041]
Current hypotheses of the etiology of fibromyalgia (FM) include inflammatory disorders. We evaluated the effect of a pool-aquatic exercise program (8 months, two weekly 60-min sessions) on the inflammatory cytokine production by isolated monocytes, and on the serum concentration of C-reactive protein (CRP), in a group of female FM patients. Monocytes from FM patients released more IL-1 beta, TNFa, IL-6, and IL-10 than those from an age-matched control group of healthy women (HW). This inflammatory disorder in FM women was also manifested by high circulating concentrations of CRP. Increased IL-6 with a concomitant decreased TNFa spontaneous release was found after 4 months (midway through) of the exercise program. At the end of the program (8 months), monocytes from FM patients showed diminished spontaneous production of pro-/anti-inflammatory cytokines, with a similar spontaneous release of IL-1 beta and IL-6 to that of HW, but a lower production of TNFa and higher of IL-10. Lipopolysaccharide-induced production of IL-1 beta, TNFa, IL-6, and IL-10 also decreased at the end of the exercise program, although IL-10 remained higher than HW. The anti-inflammatory effect of the exercise program was also corroborated by a decrease in the circulating CRP concentration. Exercise also improved the health-related quality of life of FM patients.
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