期刊
RSC ADVANCES
卷 5, 期 59, 页码 47341-47352出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra05624a
关键词
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资金
- Department of Science and Technology, New Delhi, India (DST-TSD) [DST/TSG/NTS/2011/73]
- DST-EMEQ [SB/EMEQ-185/2013]
- Defence Research and Development Organisation, New Delhi, India, (DRDO) [ERIP/ER/1103949/M/01/1513]
- UGC, New Delhi, India [F. 30-1/2013(SA-II)/RA-2012-14-NEW-SC-TAM-3240]
The key property in the fabrication of a biomaterial is to facilitate the replacement and/or regeneration of damaged tissues and organs. To obtain such a biomaterial, we fabricated a triple mineral (strontium, magnesium and zinc) substituted hydroxyapatite/gelatin (M-HAP/Gel) nanocomposite coating on electron beam treated titanium (Ti) metal. The influence of gelatin concentration in M-HAP was studied to investigate its effect on morphological changes, crystallinity, mechanical and anticorrosion properties. The M-HAP/Gel nanocomposite coating (with 3 wt% gelatin) on treated Ti resulted in better mechanical and anticorrosion properties as a consequence of the electron beam treatment of Ti. A reduced number of bacterial colonies were observed for the M-HAP/Gel composite against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) microbes which evidences a lower chance of implant failure after implantation. Moreover, the cell proliferation assay, live/dead staining of MT3C3-E1 cells and cell viability of fibroblast stem cells on the resultant nanocomposite revealed that the M-HAP/Gel composite will definitely be an effective implant material for better cell growth in orthopedic applications.
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