期刊
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
卷 77, 期 5, 页码 372-388出版社
WILEY
DOI: 10.1111/sji.12047
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资金
- Norwegian Research Council [172292]
- EU 7th Framework Programme ('Multi-disciplinary University Traditional Health Initiative (MUTHI)' [266005]
The aim of this study was to investigate whether the pectic polysaccharides BP-II, Oc50A1.I.A and CC1P1 isolated from the Malian medicinal plants Biophytum petersianum, Opilia celtidifolia and Cola cordifolia, respectively, were able to protect against Streptococcus pneumoniae infection in mice. The pectin preparations were administered intraperitoneally 3h before challenge with S.pneumoniae serotype 6B. Blood samples were obtained from all animals before and at 3h, 24h and 72h after challenge with the pneumococci. The number of bacteria in blood was recorded and the blood concentration of a range of cytokines measured. The pretreatment with BP-II, Oc50A1.I.A and CC1P1 demonstrated a protective activity against S.pneumoniae serotype 6B infection, albeit at different range of concentrations. The pectins showed no direct antibacterial effects towards S.pneumonia; however, they induced the production of a range of cytokines and chemokines. We have previously shown that BP-II, Oc50A1.I.A and CC1P1 exhibit complement fixation activity and also that BP-II and Oc50A1.I.A stimulate macrophages to produce NO. The observed clinical effect might therefore be linked to the ability of the pectic polysaccharides to stimulate the innate immune system.
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