期刊
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
卷 74, 期 4, 页码 377-382出版社
WILEY
DOI: 10.1111/j.1365-3083.2011.02583.x
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资金
- PHS [K99DE018958, R21AI081952]
- Center for Orphan Autoimmune Disorders
- Sjogren's Syndrome Foundation
Sjogren's syndrome (SS) is an autoimmune disease targeting the exocrine glands resulting in xerostomia/keratoconjunctivitis sicca. Presently, we examined the levels and clinical correlations of IL-22 in SS. Patients with SS together with normal controls were randomly selected. IL-22 was detected at significantly higher levels in sera of patients with SS. The levels of IL-22 present in sera showed statistically significant direct correlations with hyposalivation, anti-SSB, anti-SSA/SSB combined, hypergammaglobulinemia and rheumatoid factor. IL-22 showed a direct correlation with major clinical parameters. The data suggest that IL-22 plays a critical role in the development of SS, and further study is needed to examine its function in human SS.
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