期刊
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
卷 44, 期 5, 页码 564-570出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00365520902745062
关键词
Biological markers; gastric mucosa; pathology; gastrins; omeprazole; analogs derivatives; pepsinogens
资金
- AstraZeneca
- Orion-Farmos Oy
- Finnish Medical Association Duodecim
- Novartis
- GlaxoSmithKline
- Dynogen
- Tioga
Objective. Proton-pump inhibitors (PPIs), H2 receptor antagonists (H2RAs) and antacids/alginates reduce intragastric acidity and may thus influence normal gastric physiology. The purpose of this study was to examine the effect of these compounds on serum levels of amidated gastrin-17 (G-17) and pepsinogens (PGI PGII) in a large, random, adult Swedish population sample with uninfected stomach mucosa. Material and methods. The initial sample subjects (n=1000, mean age 50 years, range 20-80 years) completed a questionnaire on the use of acid inhibitory drugs 1 week and/or 3 months before study entry. All subjects (n=590) with normal gastric mucosa as delineated by serum biomarkers were included. Among them, serum levels of PGI, PGII and G-17 were compared between those who used acid inhibitory drugs and those who did not. Results. The serum levels of G-17 or pepsinogens in the subjects who reported use of H2RAs (n=18) or antacid/alginates (n=66) during the previous 3 months did not differ from those in non-users (n=471). However, the median levels of G-17 and pepsinogens were significantly (p0.001) higher among the PPI users (n=35) than among non-users: the levels were approximately doubled. The ratio of PGI/PGII was, however, similar between PPI users and non-users, or those using antacids/alginates or H2RAs. Among subjects using PPIs, the serum levels of pepsinogens correlated positively (p0.01) with the serum levels of G-17. Conclusions. PPIs but not antacids/alginates or H2RAs markedly increase the fasting levels of serum amidated G-17 and pepsinogens among ordinary patients in everyday clinical practice.
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