Copper-catalyzed C-H alkylation of 8-aminoquinolines via 8-amide chelation assistance

A copper-catalyzed 8-amide chelation- assisted C-H alkylation of 8-aminoquinolines is described. The secondary and tertiary alkyl carboxylic acids can be used as alkylating agents. This reaction allows for the highly regioselective preparation of C2-adamantyl 8-aminoquinoline scaffolds by the decarboxylative alkylation catalytic system.