Synthesis of alkyl tetraphosphonates: First example of nickel catalyst for H-phosphonates addition to diynes

Efficient algorithm was developed for the analysis of products of the catalytic reaction of diynes multiphosphorylation based on combined application of P-31 NMR DOSY spectra and HPLC-MS method. Using this analytical approach the reaction of H-phosphonates addition to diynes was investigated and a simple synthetic procedure got alkyl tetraphosphonates preparation was developed.