Synthesis of epothilone D with the forced application of oxycyclopropane intermediates

The total synthesis of epothilone D with six-fold application in the intermediate stages of successive cyclopropanation - opening or cleavage of the three-membered ring was performed. These transformations underlie the new stereoselective method developed for coupling fragments C-7-C-12 and C-13-C-21 in the target molecule.