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The increase in the proportion of nervous animals bred for catatonia: The participation of central adrenoreceptors in catatonic reactions

期刊

RUSSIAN JOURNAL OF GENETICS
卷 48, 期 11, 页码 1141-1147

出版社

MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1022795412100092

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  1. Russian Foundation for Basic Research [10-04-00616-a]
  2. Presidium of the Russian Academy of Sciences
  3. Presidium of the Siberian Branch of the Russian Academy of Sciences

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Using a large amount of breeding material, the idea of D.K. Belyaev on the role of selection in the appearance of new behavioral and neuronal forms was confirmed. Experiments were performed using rats of the GC (genetics + catatonia) strain, which are prone to passive defensive reactions of cataleptic freezing. At the current breeding stage, elevation of the proportion of so-called nervous animals was demonstrated, both with respect to the expression of such reactions and their frequency. At this breeding stage, in the brains of GC rats, the mRNA levels of alpha 1A- and alpha 2A-adrenoreceptor genes were determined. A decrease of alpha 1A-adrenoreceptor gene expression in the midbrain and medulla oblongata, along with elevation of alpha 2A-adreno-receptor gene expression in the frontal cortex was observed. It was suggested that changes in the expression of alpha-adrenoreceptor genes could be caused by an increase in the proportion of nervous animals and could contribute to the akinetic behavioral component in GC rats.

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