期刊
RUSSIAN JOURNAL OF GENETICS
卷 48, 期 11, 页码 1141-1147出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1022795412100092
关键词
-
资金
- Russian Foundation for Basic Research [10-04-00616-a]
- Presidium of the Russian Academy of Sciences
- Presidium of the Siberian Branch of the Russian Academy of Sciences
Using a large amount of breeding material, the idea of D.K. Belyaev on the role of selection in the appearance of new behavioral and neuronal forms was confirmed. Experiments were performed using rats of the GC (genetics + catatonia) strain, which are prone to passive defensive reactions of cataleptic freezing. At the current breeding stage, elevation of the proportion of so-called nervous animals was demonstrated, both with respect to the expression of such reactions and their frequency. At this breeding stage, in the brains of GC rats, the mRNA levels of alpha 1A- and alpha 2A-adrenoreceptor genes were determined. A decrease of alpha 1A-adrenoreceptor gene expression in the midbrain and medulla oblongata, along with elevation of alpha 2A-adreno-receptor gene expression in the frontal cortex was observed. It was suggested that changes in the expression of alpha-adrenoreceptor genes could be caused by an increase in the proportion of nervous animals and could contribute to the akinetic behavioral component in GC rats.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据