Determination of Levofloxacin Hydrochloride with Multiwalled Carbon Nanotubes-Polymeric Alizarin Film Modified Electrode

Multiwalled carbon nanotubes-polymeric alizarin film modified electrode was made. The electrochemical behavior of levofloxacin hydrochloride on modified electrode was studied with cyclic voltammetry, linear sweep voltammetry and chronopotentiometry. The results indicated that the electrical oxidation of levo-floxacin hydrochloride on MWNT-PAR electrode, in HAc-NaAc buffer solution at pH 4.2 was irreversible and was controlled by diffusion. Some important parameters m, n, D, E(D), Delta S(rc) and Delta H(rc) of the electrochemical pro-cess were evaluated. Good linearity relationship between peak current and its concentration in the range of 5.0 x 10(-6)-1.0 x 10(-4) mol l(-1) was found, of which the equation was I(p)(A) = -5.456 x 10(-6) - 0.2667c, the correlative coefficient r = -0.9976 and detect limitation was 4.0 x 10(-7) mol l(-1). The recovery of levofloxacin hydro-chloride in levofloxacin hydrochloride injection was between 94.6 and 104.7%.