Synthesis and crystal structure of complex [Mn(Imdc)(2)(H2O)(2)] center dot 2H(2)O and its interaction with DNA

Under hydrothermal conditions, the complex [Mn(lmdc)(2)(H2O)(2)] center dot 2H(2)O (I) was synthesized and characterized by elemental analysis and IR spectrum (HImdc = 4,5-imidazofedicarboxylic acid). The crystal structure of I was determined by single-crystal X-ray diffraction (crystallizing in the monoclinic crystal system, P (2)/c space group, a = 11.000(2), b = 7.1281(14), c = 12.696(3) , beta = 122.45(3), Z = 2. In I, the Mn2+ ion was chelated by two Imdc with one of their nitrogen atoms and a carboxylic oxygen atom, while two water molecules occupy the axial position of the Mn atom forming a distorted octahedral geometry. Three-dimensional structure of I was formed by intermolecular hydrogen bonds. UV-Vis and fluorescence spectra of I interacting with DNA show that insertion is the main binding mode between I and fish sperm DNA. Gel electrophoresis shows that I cleaves both supercoiled and circular pBR322 DNA to form a small molecular fragment.