期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 40, 期 3, 页码 336-342出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162014030091
关键词
benzimidazole; perimidine; bisbenzimidazole; microwave synthesis; iminoester hydrochloride; lipase inhibition
This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by H-1 NMR and C-13 NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.
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