期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 37, 期 6, 页码 672-706出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162011060100
关键词
carbohydrate; glycosaminoglycan; heparin; anticoagulant; mimetic of heparin
资金
- Russian Foundation for Basic Research [10-03-00980]
Natural glycosaminoglycan heparin remains the most commonly prescribed anticoagulant for hospitalized patients in modern medical practice. Unfortunately, its administration can be accompanied by a series of clinical side effects, including thrombocytopenia and bleeding. This determines the urgency of the development of alternative anticoagulant drugs based on modified heparin and polyanionic oligo- and polysaccharide derivatives, such as sulfated glucans, phosphomannans, and fucoidans. Here we review work on the synthesis of oligosaccharides corresponding to low-molecular-weight heparin fragments and their derivatives, as well as oligosaccharides imitating parts of heparin chains that are responsible for biological activity. The reviewed works were aimed at developing pharmaceutical preparations lacking the aforementioned disadvantages of heparin.
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