期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 35, 期 1, 页码 62-67出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162009010087
关键词
deoxyguanosine; quenching; telomere
资金
- Department of Science and Technology, New Delhi
A modified fluorescent probe U(F)AA AAT CTC CGC CGC was synthesized using the nucleoside analogue 3'-O-(N,N'-diisopropylamino-2-cyanoethoxyphosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-(dansyl-1-sulfonamidohexylaminocarbonyl)uridine for hybridization studies with perfectly matched (U/A) complementary DNA and with a DNA strand having similar G-rich telomeric units at their 3'-ends. Data on the thermal stability and decrease in fluorescence intensity due to the presence of dG units clearly demonstrated the potential application of this approach in DNA diagnostics in homogeneous hybridization assays.
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