Synthesis of N,N'-bis(alkyloxymethyl)piperazines and examination of their antimicrobial properties

Three-component condensation of piperazine with formaldehyde and aliphatic alcohols was employed for elucidating the possibility to synthesize N,N'-bis(alkyloxymethyl)piperazines. The structure of the resulting compounds was identified by 1H NMR spectroscopy. The antimicrobial properties of these compounds were examined with respect to microorganisms that infect cooling lubricants and lubricant oils.