Synthesis and antitumor activity of novel tetrakis[4-(closo-carboranylthio)tetrafluorophenyl]porphyrins

Novel neutral and anionic fluorinated carboranylporphyrins for boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) were synthesized by the reaction of 5,10,15,20-pentafluorophenylporphyrin and its copper(II), zinc(II), and palladium(II) complexes with closo-mercaptocarboranes and cesium 1-mercapto-1-carba-closo-dodecaborate. Preliminary evaluation of biological activity reveals that anionic carboranylporphyrins are promising agents for BNCT and PDT.