期刊
RUSSIAN CHEMICAL BULLETIN
卷 59, 期 1, 页码 232-235出版社
SPRINGER
DOI: 10.1007/s11172-010-0067-6
关键词
O-sulfation; anticoagulant; lignan; flavonoid; secoisolariciresinol; isolariciresinol; dihydroquercetin; myo-inositol
资金
- Russian Foundation for Basic Research [08-04-00812, 09-03-92661-ind]
- Russian Academy of Sciences, Division of Chemistry and Materials Science [5]
Persulfated derivatives of natural polyhydroxy compounds, such as lignans secoisolariciresinol, and isolariciresinol, flavonoid dihydroquercetin, and myo-inositol, have been synthesized. The ability of these compounds to inhibit the intrinsic pathway of blood coagulation (APTT-test) and to reduce the activity of coagulation factor Xa in the presence of antithrombin(III) has been studied.
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