期刊
RNA
卷 19, 期 6, 页码 737-739出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.036319.112
关键词
microRNA; Toll-like receptor; ligand; exosome
资金
- National Natural Science Foundation of China [81101330, 31271378, 81250044, J1103512]
- Natural Science Foundation of Jiangsu Province [BK2011013, BK2012014]
It has long been known that microRNAs (miRNAs) can regulate target gene expression at the post-transcriptional level. Recent studies, however, have revealed that miRNAs can also be transported from donor cells to recipient cells, in which these RNAs function in a novel manner as ligands of Toll-like receptors. Here, we review the latest findings on these unconventional miRNAs, with special emphasis on their biological significance.
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