期刊
RNA
卷 15, 期 6, 页码 1090-1099出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.1545309
关键词
3 ' UTRs; RNA decay; RNA-protein interactions; translational regulation
资金
- A*STAR National Science Scholarship from Singapore
- NIH [HG003747, 144-MK47, 144-QS25]
- Khorana Summer Fellowship
PUF proteins specifically bind mRNAs to regulate their stability and translation. Here we focus on the RNA-binding specificity of a C. elegans PUF protein, PUF-11. Our findings reveal that PUF-11 binds RNA in multiple modes, in which the protein can accommodate variable spacings between two distinct recognition elements. We propose a structural model in which flexibility in the central region of the protein enables the protein to adopt at least two distinct structures, one of which results in base flipping.
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