期刊
RNA
卷 14, 期 5, 页码 822-828出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.988608
关键词
AdoMet; S-adenosylmethionine; riboswitches; scaffold; Streptomyces
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NCRR NIH HHS [RR19895-02, S10 RR019895] Funding Source: Medline
- NHGRI NIH HHS [R01 HG002602, R01 HG02602] Funding Source: Medline
- NIGMS NIH HHS [GM 068819, R01 GM068819] Funding Source: Medline
A novel family of riboswitches, called SAM-IV, is the fourth distinct set of mRNA elements to be reported that regulate gene expression via direct sensing of S-adenosylmethionine (SAM or AdoMet). SAM-IV riboswitches share conserved nucleotide positions with the previously described SAM-I riboswitches, despite rearranged structures and nucleotide positions with family-specific nucleotide identities. Sequence analysis and molecular recognition experiments suggest that SAM-I and SAM-IV riboswitches share similar ligand binding sites, but have different scaffolds. Our findings support the view that RNA has considerable structural versatility and reveal that riboswitches exploit this potential to expand the scope of RNA in genetic regulation.
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