期刊
RNA BIOLOGY
卷 11, 期 4, 页码 295-297出版社
LANDES BIOSCIENCE
DOI: 10.4161/rna.28342
关键词
RNA polymerase; transcription; termination; RNA hairpin; RNA secondary structure; elongation complex; pausing; molecular evolution; Last Universal Common Ancestor
资金
- Wellcome Trust [102851/Z/13/Z] Funding Source: Wellcome Trust
- BBSRC [BB/L010003/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L010003/1] Funding Source: researchfish
- Wellcome Trust [102851/Z/13/Z] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Multi-subunit RNA polymerases are the enzymes that perform transcription in all living organisms and that have emerged before the divergence of domains of life. The structures of catalytic cores and their functions during elongation step of transcription cycle are very similar for all multi-subunit RNA polymerases. In contrast, the mechanisms for terminating the RNA synthesis have seemingly diverged in modern RNA polymerases. However, the recent finding that, much like during bacterial transcription, RNA secondary structure is involved in termination by eukaryotic RNA polymerase III (pol III), suggests that RNA-dependent termination may have emerged before the divergence of bacterial and archaeal/eukaryotic RNA polymerases. In the case of pol III, the terminating RNA secondary structures are not dedicated hairpins, but are formed by the bodies of highly structured transcripts, which are clearly the remnants from the RNA-protein world. Here I discuss the similarities and differences of RNA-dependent mechanisms of termination of transcription by bacterial RNA polymerase and pol III.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据