期刊
RNA BIOLOGY
卷 11, 期 12, 页码 1508-1518出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/15476286.2014.992271
关键词
tRNA modification; S-adenosylmethionine; Radical-SAM enzymes; Wybutosine; Fe-S clusters
资金
- ANR Blanc grant INSERAD
- Region Rhone-Alpes grants CIBLE
- NIH [2U54GM75026]
Over the last 10years, significant progress has been made in understanding the genetics, enzymology and structural components of the wybutosine (yW) biosynthetic pathway. These studies have played a key role in expanding our understanding of yW biosynthesis and have revealed unexpected evolutionary ties, which are presently being unraveled. The enzymes catalyzing the 5 steps of this pathway, from genetically encoded guanosine to wybutosine base, provide an ensemble of amazing reaction mechanisms that are to be discussed in this review article.
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