期刊
RNA BIOLOGY
卷 10, 期 12, 页码 1798-1806出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.27177
关键词
non-coding RNA; RNA processing; tRNA halves; tRNA-derived fragments; translation regulation; RNA silencing; RNA fragmentation
资金
- Swiss National Science Foundation [31003A_143388/1]
- Austrian Science Foundation [Y315]
- Swiss National Science Foundation (SNF) [31003A_143388] Funding Source: Swiss National Science Foundation (SNF)
- Austrian Science Fund (FWF) [Y 315] Funding Source: researchfish
Post-transcriptional cleavage of RNA molecules to generate smaller fragments is a widespread mechanism that enlarges the structural and functional complexity of cellular RNomes. Substrates for such RNA fragmentations are coding as well as non-protein-coding RNAs. In particular, fragments derived from both precursor and mature tRNAs represent one of the rapidly growing classes of post-transcriptional RNA pieces. Importantly, these tRNA fragments possess distinct expression patterns, abundance, cellular localizations, or biological roles compared with their parental tRNA molecules. Here we review recent reports on tRNA cleavage and attempt to categorize tRNA pieces according to their origin and cellular function. The biological scope of tRNA-derived fragments ranges from translation control, over RNA silencing, to regulating apoptosis, and thus clearly enlarges the functional repertoire of ncRNA biology.
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