期刊
RNA BIOLOGY
卷 10, 期 4, 页码 627-635出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.24393
关键词
RNA turnover; riboregulation; post-transcriptional network; ribonuclease; messenger RNA; small regulatory RNA
资金
- Wellcome Trust
- BBSRC
RNA enables the material interpretation of genetic information through time and in space. The creation, destruction and activity of RNA must be well controlled and tightly synchronized with numerous cellular processes. We discuss here the pathways and mechanism of bacterial RNA turnover, and describe how RNA itself modulates these processes as part of decision-making networks. The central roles of RNA decay and other aspects of RNA metabolism in cellular control are also suggested by their vulnerability to sabotage by phages; nonetheless, RNA can be used in defense against phage infection, and these processes are described here. Salient aspects of RNA turnover are drawn together to suggest how it could affect complex effects such as phenotypic diversity in populations and responses that persist for multiple generations.
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