期刊
RNA BIOLOGY
卷 10, 期 4, 页码 602-609出版社
LANDES BIOSCIENCE
DOI: 10.4161/rna.23664
关键词
RNA degradation; Rho-independent terminators; exoribonucleases; oligo(A) tails; poly(A) polymerase; polyadenylation; protein Hfq
资金
- Centre National de la Recherche scientifique [UPR9073]
- University Paris-Diderot
- Agence Nationale de la Recherche: asSUPYCO [ANR-12-BSV6-0007-03]
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV6-0007] Funding Source: Agence Nationale de la Recherche (ANR)
Discovered in eukaryotes as a modification essential for mRNA function, polyadenylation was then identified as a means used by all cells to destabilize RNA. In Escherichia coli, most accessible 3 RNA extremities are believed to be potential targets of poly(A) polymerase I. However, some RNAs might be preferentially adenylated. After a short statement of the current knowledge of poly(A) metabolism, we discuss how Hfq could affect recognition and polyadenylation of RNA terminated by Rho-independent terminators. Comparison of RNA terminus leads to the proposal that RNAs harboring 3 terminal features required for Hfq binding are not polyadenylated, whereas those lacking these structural elements can gain the oligo(A) tails that initiate exonucleolytic degradation. We also speculate that Hfq stimulates the synthesis of longer tails that could be used as Hfq-binding sites involved in non-characterized functions of Hfq-dependent sRNAs.
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