期刊
RNA BIOLOGY
卷 9, 期 3, 页码 231-241出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.18974
关键词
microRNA; let-7; mir-100; mir-125; miRNA evolution
资金
- European Regional Development Fund (ERDF)
- Free State of Saxony
- European Social Fund
- European FP-7 project QUANTOMICS [222664]
T he increase of bodyplan complexity in early bilaterian evolution is correlates with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two known microRNAs whose origins date back before the bilaterian ancestor is mir-100. In Bilateria, it appears stably associated in polycistronic transcripts with let-7 and mir-125, two key regulators of development. In vertebrates, these three microRNA families have expanded to form a complex system of developmental regulators. In this contribution, we disentangle the evolutionary history of the let-7 locus, which was restructured independently in nematodes, platyhelminths, and deuterostomes. The foundation of a second let-7 locus in the common ancestor of vertebrates and urochordates predates the vertebrate-specific genome duplications, which then caused a rapid expansion of the let-7 family.
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