期刊
RNA BIOLOGY
卷 9, 期 12, 页码 1498-1503出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.22311
关键词
plasmid stability; post-segregational killing; peptide toxins; antisense RNA; toxin-antitoxin
资金
- Public Health Service grant [GM55544]
- National Science Foundation Grant [MCB-9723098]
- Division of Basic Biomedical Sciences, Sanford School of Medicine
The par post-segregational killing locus present on Enterococcus faecalis plasmid pAD1 was the first Type I toxin-antitoxin system described in Gram-positive bacteria. Translation of the 33 amino acid Fst toxin, encoded on RNA I, is suppressed by a 66 nucleotide regulatory RNA, RNA II. RNA I and RNA II are transcribed convergently and interact at dispersed regions of complementarity, establishing a stable complex that accumulates in plasmid-containing cells. RNA II is slowly removed from the complex, allowing translation of RNA I in plasmid-free segregants. Intramolecular structures are also important for regulating translation of RNA I. The Fst toxin contains a putative transmembrane domain and is believed to exert its function at the bacterial cytoplasmic membrane, although its precise target and mode of action have yet to be determined. Numerous chromosomal homologs of pAD1 par have been identified in Gram-positive bacteria suggesting that this locus may play important roles in cellular function.
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