期刊
RNA BIOLOGY
卷 9, 期 6, 页码 742-750出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.20018
关键词
microRNA; miR-146; miR-155; RNAi; effector
资金
- BMBF (German Ministry of Education and Research) [NGFN 01GS0806/JV-BMBF-01, 0315836]
- NGFN (German Ministry of Education and Research) [NGFN 01GS0806/JV-BMBF-01, 0315836]
- Bavarian Ministry of Sciences, Research and the Arts in the framework of the Bavarian Molecular Biosystems Research Network
MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression. In addition to their involvement in a wide range of physiological and pathological processes, including viral infections, microRNAs are increasingly implicated in the eukaryotic response to bacterial pathogens. Recent studies have characterized changes in host microRNA expression following infection with exclusively extracellular (Helicobacter pylori) or intracellular (Salmonella enterica) Gram-negative bacteria, as well as in the response to Gram-positive (Listeria monocytogenes) and other pathogens (Mycobacterium and Francisella species). In this review, we discuss the emerging roles of microRNAs in mammalian host signaling and defense against bacterial pathogens.
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