期刊
RNA BIOLOGY
卷 9, 期 6, 页码 731-741出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.19985
关键词
ncRNAs; linc; lnc; macro; genomic imprinting; RNA-seq
资金
- DOC Fellowship of Austrian Academy of Sciences
- GEN-AU III Epigenetic Control Of Cell Identity [GZ200.141/1-VI/12009]
- Austrian Science Fund SFB RNA Regulation Of The Transcriptome [F4302-B09]
- Austrian Science Fund (FWF) [W1207] Funding Source: Austrian Science Fund (FWF)
Long non-protein-coding RNAs (lncRNAs) have been shown in the past ten years to comprise a major part of the mammalian transcriptome and are predicted from their highly specific expression patterns, to play a role in regulating protein-coding gene expression in development and disease. Many lncRNAs particularly those lying in imprinted clusters, are predominantly unspliced 'macro' transcripts that can also show a low level of splicing, and both the unspliced and spliced transcript have the potential to be functional. Three known imprinted macro lncRNAs have been shown to silence from three to ten genes in cis in imprinted gene clusters. We review here the potential for functional macro lncRNAs, defined here as 'inefficiently-spliced lncRNAs' to play a wider cis-regulatory role in the mammalian genome. This potential has been underestimated by the inability of current RNA-seq technology to annotate unspliced macro lncRNAs.
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