期刊
RNA BIOLOGY
卷 9, 期 9, 页码 1161-1166出版社
LANDES BIOSCIENCE
DOI: 10.4161/rna.21630
关键词
Enoplea; Mermithidae; mitochondrial tRNA; D-loop; T-loop
资金
- Centre National de la Recherche Scientifique (CNRS)
- Universite de Strasbourg, Association Francaise contre les Myopathies [MNM1 2009]
- ANR MITOMOT [ANR-09-BLAN-0091-01]
- Deutsche Forschungsgemeinschaft (Deep Metazoan Phylogeny) project [SPP-1174, STA 850/3-2, STA 850/2]
- French-German PROCOPE program [DAAD D/0628236, EGIDE PHC 14770PJ]
- French-German University (DFH-UFA) [CT-0810]
- German Academic Exchange Service [DAAD D/10/43622]
- College Doctoral Europaen (CDE), Universite de Strasbourg
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0091] Funding Source: Agence Nationale de la Recherche (ANR)
The mitochondrial genome of metazoan animal typically encodes 22 tRNAs. Nematode mt-tRNAs normally lack the T-stem and instead feature a replacement loop. In the class Enoplea, putative mt-tRNAs that are even further reduced have been predicted to lack both the T- and the D-arm. Here we investigate these tRNA candidates in detail. Three lines of computational evidence support that they are indeed minimal functional mt-tRNAs: (1) the high level of conservation of both sequence and secondary structure, (2) the perfect preservation of the anticodons, and (3) the persistence of these sequence elements throughout several genome rearrangements that place them between different flanking genes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据