期刊
RNA BIOLOGY
卷 8, 期 1, 页码 49-54出版社
LANDES BIOSCIENCE
DOI: 10.4161/rna.8.1.14066
关键词
archaea; exosome; localization; membrane; prokaryotes; protein complex; ribonuclease; RNA degradation; RNA processing; Sulfolobus
The archaeal exosome is a prokaryotic protein complex with RNA processing and degrading activities. Recently it was shown that the exosome is localized at the periphery of the cell in the thermoacidophilic archaeon Sulfolobus solfataricus. This localization is most likely mediated by the archaeal DnaG protein and depends on (direct or indirect) hydrophobic interactions with the membrane. A localization of RNA degrading proteins and protein complexes was also demonstrated in several bacteria. In bacteria a subcellular localization was also shown for substrates of these proteins and protein complexes, i.e., chromosomally encoded mRNAs and a small RNA. Thus, despite the missing compart-mentalization, a spatial organization of RNA processing and degradation exists in prokaryotic cells. Recent data suggest that the spatial organization contributes to the temporal regulation of these processes.
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