期刊
RNA BIOLOGY
卷 7, 期 5, 页码 582-585出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.7.5.13216
关键词
lncRNA; HOTAIR; chromatin; metastasis; PRC2
资金
- Howard Hughes Medical Institute Funding Source: Medline
Long noncoding RNAs (lncRNAs) are pervasively transcribed and critical regulators of the epigenome. 1,2 These long, polyadenylated RNAs do not code for proteins, but function directly as RNAs, recruiting chromatin modifiers to mediate transcriptional changes in processes ranging from X-inactivation (XIST) to imprinting (H19). 3 The recent discovery that lncRNA HOTAIR can link chromatin changes to cancer metastasis(4) furthers the relevance of lncRNAs to human disease. Here, we discuss lncRNAs as regulatory modules and explore the implications for disease pathogenesis.
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