期刊
RNA BIOLOGY
卷 7, 期 3, 页码 316-321出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.7.3.11913
关键词
RNase J1; RNase J2; 5 '-to-3; exoribonuclease; endoribonuclease; complex
资金
- CNRS [UPR 9073]
- Universite Paris VII-Denis Diderot
- Agence Nationale de la Recherche (ANR)
The discovery of the paralogous ribonucleases J1 and J2 has been a major advance in the study of RNA maturation and decay in Bacillus subtilis and related organisms. RNase J1 was the first bacterial enzyme shown to possess 5'-to-3' exoribonuclease activity, reversing a dogma that suggested this type of activity was unique to eukaryotic mRNA decay. RNase J1 and J2 form a complex that also has endonuclease activity and these enzymes have been shown to play a key role in the turnover and maturation of many RNAs in B. subtilis. Here, I describe recent progress in our understanding of the role of these enzymes in RNA metabolism in this organism and argue that the 5'-to-3' exoribonuclease activity may be the more important of the complex's two modes of action.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据