期刊
RNA BIOLOGY
卷 7, 期 5, 页码 528-533出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.7.5.12262
关键词
miRNA; pri-miRNA; miR-124; neuronogenesis; apical precursor; basal precursor; neuron; cortical plate
资金
- intramural SISSA funding
miRNAs are essential post-transcriptional modulators affecting cell identity and fate, with a central role in cellular and developmental processes. The brain-enriched neuronal specific miRNAs-124 has been identified as a promoter of neuronogenesis in various conditions, in vitro and in vivo, with a potential role in regulating also activities of post-mitotic neurons, such as synaptic plasticity and memory formation. In this point of view, we recapitulate the main experimental findings substantiating the positive correlation between miR-124 expression and neuronogenesis progression. Then, we describe the impact of miR-124 on the molecular network driving the profound changes which take place in differentiating neuronal cells. Finally, we consider the possibility of a post-transcriptional modulation of miR-124 biogenesis, which may finely regulate-in turn-the activities of miR-124 in neural precursor cells.
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