期刊
RNA BIOLOGY
卷 6, 期 4, 页码 426-433出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.6.4.8841
关键词
RNA binding proteins; post-transcriptional regulation; SAGE; MPSS; oncogenomics; cancer; gene expression analysis
资金
- FAPESP
- Fogarty International center, NIH [5D43TW007015-02]
- Medical School (UTHSCSA)
- International Human Frontier Science Program
RNA binding proteins (RBPs) are involved in several post-transcriptional stages of gene expression and dictate the quality and quantity of the cellular proteome. When aberrantly expressed, they can lead to disease states as well as cancers. A basic requirement to understand their role in normal tissue development and cancer is the build of comprehensive gene expression maps. In this direction, we generated a list with 383 human RBPs based on the NCBI and EMSEMBL databases. SAGE and MPSS were then used to verify their levels of expression in normal tissues while SAGE and microarray datasets were used to perform comparisons between normal and tumor tissues. As main outcomes of our studies, we identified clusters of co-expressed or co-regulated genes that could act together in the development and maintenance of specific tissues; we also obtained a high confidence list of RBPs aberrantly expressed in several tumor types. This later list contains potential candidates to be explored as diagnostic and prognostic markers as well as putative targets for cancer therapy approaches.
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