期刊
RNA BIOLOGY
卷 6, 期 3, 页码 321-323出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.6.3.8807
关键词
LNA; oligonucleotides; antisense; SiRNA; miRNA; aptamers; RNA targeting
资金
- Danish National Research Foundation
Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides. The remarkable proper-ties of LNA have led to applications within various gene silencing strategies both in vitro and in vivo. In the present review, we highlight the uses of LNA for regulation of gene expression with emphasis on RNA targeting.
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