期刊
RNA BIOLOGY
卷 6, 期 3, 页码 324-328出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.6.3.8871
关键词
microRNAs; therapeutics; biomarkers; genomics; antagonists; agonists
Genomic studies have shown that a microRNA(miRNA) can post-transcriptionally regulate hundreds of other genes, providing challenges and opportunities for therapeutic development. Profiling studies have placed several miRNAs within transcriptional pathways linked to disease, and oligonucleotide therapeutics are being developed that modulate miRNA activity. The involvement of miRNAs in diverse genetic pathways across human tissues suggests that miRNAs will also be useful as biomarkers for disease and tissue injury.
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