期刊
RNA BIOLOGY
卷 6, 期 2, 页码 100-106出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/rna.6.2.7854
关键词
ncRNA; non-coding RNA; macro ncRNA; genomic imprinting; imprinted clusters
资金
- GEN-AU Epigenetic Plasticity of the Mammalian Genome [GZ200.141/1-VI/2006]
- EU-FW6 IP 'HEROIC' [LSHG-CT-2005-018883]
- NoE 'The Epigenomc' [LSHG-CT-2004-053433]
- FWF SFB F17 Modulators of RNA Fate and Function [SFB-P1718 B10]
- FWF-DK [W1207-BO9]
In mammals, imprinted genes are clustered and at least one gene in each imprinted cluster is a long i.e., macro non-coding (nc) RNA. Most genes in a cluster show concordant parental-specific expression but the ncRNA is the odd one out, and is expressed from the opposite parental chromosome. While reciprocal expression between imprinted macro non-coding RNAs and flanking mRNA genes is indicative of a functional role, only two of three tested macro ncRNAs have been shown to induce imprinted gene expression. The two known functional imprinted macro non-coding RNAs are both RNAPII transcripts with unusual transcriptional properties that may be functionally relevant and their analysis may shed light on the function of non-coding RNAs that have been shown to comprise the majority of the mammalian transcriptome.
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