期刊
RHEUMATOLOGY INTERNATIONAL
卷 34, 期 5, 页码 625-629出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-013-2882-1
关键词
Growth arrest-specific protein 6 (Gas6); Nephritis; Systemic lupus erythematosus; Vasculitis
类别
资金
- National Science Council, Taiwan [NSC95-2320-B-002-081, NSC98-3112-B-002-047, NSC98-2320-B-002-021-MY2, NSC98-2320-B-002-049-MY3]
- National Taiwan University Hospital [VN-9801]
Growth arrest-specific protein 6 (Gas6) is a serum protein involved in granulocyte, platelet and endothelium interaction, and is implicated in both anti-inflammatory response as well as platelet/leukocytes activation. We investigated serum Gas6 level in different clinical manifestations of systemic lupus erythematosus (SLE). Data were collected in 83 patients with SLE and 40 non-lupus controls. The Gas6 levels were detected by enzyme-linked immunosorbent assay. Our results demonstrated that the Gas6 level was higher in SLE patients as compared to the non-lupus control subjects (SLE vs. non-lupus control, median [inter-quartile range (IQR)] 22.67 [19.40-28.60] vs. 18.97 [16.05-20.62] ng/mL, p < 0.01). Furthermore, Gas6 level was higher in patients with nephritis (nephritis vs. non-nephritis, median [IQR] 26.21 [21.17-31.61] vs. 22.22 [18.98-26.98] ng/mL, p = 0.03) and in patients with cutaneous vasculitis (vasculitis vs. non-vasculitis, median [IQR] 27.89 [23.24-34.26] vs. 22.30 [19.32-27.16] ng/mL, p = 0.03). Our results indicate that the serum Gas6 level is increased in SLE patients with lupus nephritis or cutaneous vasculitis, implicating a potential to serve as a SLE disease activity marker.
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