期刊
RHEUMATOLOGY INTERNATIONAL
卷 34, 期 7, 页码 1005-1009出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-013-2817-x
关键词
Systemic lupus erythematosus; Platelet function; Erythrocytes; White blood cells; Fibrin; Electron microscopy
类别
The study suggests that patients with systemic lupus erythematosus (SLE) present with distinct inflammatory ultrastructural changes such as platelets blebbing, generation of platelet-derived microparticles, spontaneous formation of massive fibrin network and fusion of the erythrocytes membranes. Lupoid platelets actively interact with other inflammatory cells, particularly with white blood cells (WBCs), and the massive fibrin network facilitates such an interaction. It is possible that the concerted actions of platelets, erythrocytes and WBC, caught in the inflammatory fibrin network, predispose to pro-thrombotic states in patients with SLE.
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