期刊
RHEUMATOLOGY INTERNATIONAL
卷 32, 期 4, 页码 887-893出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-010-1710-0
关键词
Rheumatoid arthritis; Th17 cells; Regulatory T cell; Cytokine
类别
资金
- Natural Science Foundation of China [30872335]
- Society Development Foundation of Zhenjiang [SH2008035]
- Medical Science and Technology Development Foundation of Jiangsu Province Department of Health [H200950]
Broken Th17/Treg balance has been reported contributing to several inflammatory autoimmune diseases. The objective of the study was to investigate whether the Th17/Treg balance was impaired in the peripheral blood of patients with rheumatoid arthritis (RA). The frequencies of Treg cells and Th17 cells and mRNA expression of transcription factor ROR gamma t and FoxP3 in peripheral blood of RA patients (n = 37) and healthy controls (n = 30) were determined by flow cytometry and real-time PCR, respectively. Eleven serum cytokines were analyzed by using cytometeric bead array (CBA). The results demonstrated that active RA patients exhibited increased peripheral Th17 cells, Th1- and Th17-related cytokines and ROR gamma t expression while decreased Treg cells and FoxP3 expression. In addition, Th17/Treg ratios were positively correlated with serum concentrations of Th1- and Th17-related cytokines. In conclusion, our results indicated that Th17/Treg balance was broken in peripheral blood, which may play an important role in the development of RA.
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