期刊
RHEUMATOLOGY INTERNATIONAL
卷 29, 期 2, 页码 173-178出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-008-0664-y
关键词
IL-17F; Polymorphisms; Behcet's disease
类别
IL-17 is a novel cytokine that is characterized by an ability to induce several types of cells to secrete proinflammatory cytokines in various inflammatory diseases. This study analyzed the influence of IL-17F gene polymorphisms on disease susceptibility and clinical features. Ninety-nine Behcet's disease (BD) patients and 114 controls were genotyped to analyze three single nucleotide polymorphisms (SNPs) including A126G, G155A, and A161G of the IL-17F gene using automated sequencing. We compared the frequencies of IL-17F alleles, genotypes, and haplotypes in patients with BD and controls using the chi-square or Fisher's exact test. Significant differences in the frequencies of allele and genotype in A126G SNP of IL-17 gene were found between BD patients and controls (P < 0.001 and P < 0.001, respectively). None of three IL-17F SNPs were associated with diverse clinical features in BD. The frequency of haplotype AA did not differ between patients with BD and controls (P = 0.985). The haplotypes, AG, and GG, have positive and inverse association with BD susceptibility (P < 0.001 and P < 0.001, respectively). These findings suggest that IL-17 gene SNPs may influence the susceptibility of BD.
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