期刊
RHEUMATOLOGY
卷 52, 期 4, 页码 590-598出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kes304
关键词
monocytes; RA; inflammation; novel therapies; biotherapies; targeting; TNF-alpha; siRNA; cPLA(2)alpha; dendrimer; animal models
类别
资金
- INSERM
- CNRS
- Paul Sabatier University Toulouse III Societe Francaise de Rhumatologie, Fondation Arthritis Courtin
Biotherapies have revolutionized the treatment of RA. However, much work is needed to understand all the mechanisms of these biotherapies, and alternatives are needed to circumvent adverse effects and the high cost of these long-lasting treatments. In this article we outline some of the approaches we have used to target monocytes/macrophages as major components of inflammation and bone homeostasis. We also discuss how anti-TNF-alpha antibodies target monocytes/macrophages in the complex mechanisms contributing to inhibition of inflammation.
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