期刊
RHEUMATOLOGY
卷 50, 期 6, 页码 1009-1018出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keq454
关键词
Fatigue; Rheumatic diseases; Cytokines; Oxidative stress; Genes
类别
资金
- Stavanger University Hospital
- Biovitrum
Chronic fatigue is a common, poorly understood and disabling phenomenon in many diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory disease. Fatigue measurement, prevalence and confounding factors such as depression, sleep disorders and pain are reviewed in the first half of the article. In the second half of the article, we describe explanatory models of fatigue and fatigue signalling, with an emphasis on cytokines and sickness behaviour, oxidative stress, mitochondrial dysfunction and the impact of certain genes on fatigue.
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