期刊
RHEUMATOLOGY
卷 49, 期 12, 页码 2264-2272出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keq224
关键词
Rheumatoid arthritis; T-lymphocytes; Tumour necrosis factor; Interleukin-17; Chemokine receptors; Adalimumab
类别
资金
- Research Foundation - Flanders (FWO)
- Abbott Laboratories (Louvain-la-Neuve, Belgium)
Methods. Intracellular IL-17, IFN-gamma and IL-4 production and CC-chemokine receptor CCR4 and CCR6 expression were analysed flow cytometrically in peripheral memory Th cells from healthy individuals, AD and RA patients. The latter were grouped by disease activity and presence or absence of adalimumab therapy. In RA patients initiating anti-TNF therapy, cytokine production by in vitro-stimulated peripheral mononuclear cells was measured by cytometric bead array. Results. The peripheral Th17 cell frequency is elevated in AD but not in RA. In RA, Th17 cells and IL-17 production increase after anti-TNF therapy, irrespective of disease activity. Th1 cells and IFN-gamma production are elevated in remission and under anti-TNF therapy. CCR6 expression is up-regulated in Th17 cells, but RA patients in remission under anti-TNF therapy have significantly lower expression than those with active disease. Conclusions. The increase in peripheral Th17 cells in RA patients after anti-TNF therapy is accompanied by a decrease in Th17-specific CCR6 expression, which might prevent homing of these potentially pro-inflammatory cells to the synovium.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据