期刊
RHEUMATOLOGY
卷 50, 期 2, 页码 330-334出版社
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keq296
关键词
Scleroderma; Systemic sclerosis; Depression; Center for Epidemiologic Studies Short Depression scale; Gastrointestinal involvement; Reflux; Constipation; University of California at Los Angeles Scleroderma Clinical trial Consortium Gastrointestinal Tract 2; 0
类别
资金
- Actelion
- United Therapeutics
- MedImmune
- National Institutes of Health [NIAMS K23 AR053858-04]
- Scleroderma Clinical Trial Consortium
- U01 National Institutes of Health/National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIH/NIAMS) [AR055057]
Methods. One hundred and fifty-two patients with SSc completed the UCLA SCTC GIT 2.0 and the Center for Epidemiologic Studies Short Depression scale (CES-D10). Patients were divided into depressed (CES-D epsilon 10) or non-depressed group (CES-D < 10) and compared using t-test or chi-square test. Multiple linear regression was used to determine associations between GI scales and depressed mood (CES-D). Results. Study participants were 84% female, 78% Caucasian and 40% had depressed mood (CES-D10 epsilon 10). Patients with depressed mood had statistically worse GI scale scores (except fecal soilage) and worse total GIT score (P < 0.05). In the multivariable model reflux and constipation scales were independently associated with worse CES-D scores (P = 0.01-0.06) Conclusion. SSc-GIT involvement is associated with depressed mood. Reflux and constipation scales of UCLA-SCTC GIT 2.0 were independently associated with CES-D. Future studies should assess if treatment of GIT symptoms will improve depressed mood in patients with SSc-GIT.
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